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Leuk Lymphoma. 2015;56(9):2613-8. doi: 10.3109/10428194.2015.1014366. Epub 2015 Mar 11.

Safety and efficacy of low-dose pre-phase before conventional-dose chemotherapy for ulcerative gastric diffuse large B-cell lymphoma.

Author information

1
a Department of Oncology , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , China.
2
b The Affiliated Cancer Hospital of Zhengzhou University , Zhengzhou , Henan , China.
3
c Department of Hematopathology , The University of Texas M. D. Anderson Cancer Center , Houston , TX , USA.
4
d Department of Pathology , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , China.

Abstract

Potentially fatal chemotherapy (CT)-related gastrorrhagia and gastric perforation in patients with gastric lymphoma present difficult problems to doctors. We retrospectively analyzed 54 patients with ulcerative gastric diffuse large B-cell lymphoma (G-DLBCL) to compare the safety and efficacy of low-dose pre-phase CT before 4-6 cycles of conventional-dose CT (n = 28) with 4-6 cycles of conventional-dose CT (n = 26) between October 2005 and August 2014. Patients who received low-dose pre-phase before conventional-dose CT showed a lower gastrorrhagia or gastric perforation rate (0% vs. 15.4%, p = 0.047) and higher complete response (CR) rate (78.6% vs. 46.2%, p = 0.023) and 5-year progression-free survival (PFS) rate (63% vs. 31%, p = 0.021) than patients who received conventional-dose CT alone. Our study suggests that low-dose pre-phase therapy before conventional-dose CT provides a safe and effective method for ulcerative G-DLBCL.

KEYWORDS:

Chemotherapy; complication; gastric lymphoma; ulcer

PMID:
25676238
DOI:
10.3109/10428194.2015.1014366
[Indexed for MEDLINE]
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