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Ann Neurol. 2015 May;77(5):895-901. doi: 10.1002/ana.24384. Epub 2015 Mar 13.

MicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder.

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Laboratory of Neurodegenerative Disorders, Department of Neurology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona; Center for Biomedical Research in Neurodegenerative Diseases, Madrid.


Recently, we reported downregulated circulating levels of the microRNAs miR-19b, miR-29a, and miR-29c in Parkinson disease. Here we investigated the expression of these microRNAs in serum samples from 56 patients with idiopathic rapid eye movement sleep behavior disorder, before and after their conversion into a synucleinopathy. Compared to controls, we found that the expression level of miR-19b is downregulated in patients with idiopathic rapid eye movement sleep behavior disorder and antedates the diagnosis of Parkinson disease and dementia with Lewy bodies after 4.67 ± 2.61 years of follow-up. Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.

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