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PLoS One. 2015 Feb 12;10(2):e0118206. doi: 10.1371/journal.pone.0118206. eCollection 2015.

Plasma elaidic acid level as biomarker of industrial trans fatty acids and risk of weight change: report from the EPIC study.

Author information

1
Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.
2
Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom; Department For Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands; Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
3
Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom; Instituto de Investigacion Sanitaria de Palma (IdISPa) and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain.
4
Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom.
5
Department of Public Health, Section of Epidemiology, Aarhus University, Aarhus, Denmark.
6
INSERM, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, Villejuif, France; University Paris Sud, UMRS 1018, Villejuif, France; Institute Gustave Roussy, Villejuif, France.
7
The German Cancer Research Center (DKFZ), Heildelberg, Germany.
8
Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany.
9
Hellenic Health Foundation, Athens, Greece; Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
10
Epidemiology and Prevention Unit, IRCCS Foundation, National Cancer Institute, Milan, Italy.
11
Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
12
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
13
Department of Community Medicine, University of Tromsø-The Arctic University of Norway, Norway.
14
Unit of Nutrition, Environment, and Cancer, Catalan Institute of Oncology-ICO, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
15
Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain; CIBER Epidemiology and Public Health CIBERESP, Spain.
16
CIBER Epidemiology and Public Health CIBERESP, Spain; Navarre Public Health Institute, Pamplona, Spain.
17
CIBER Epidemiology and Public Health CIBERESP, Spain; Andalusian School of Public Health, Granada, Spain.
18
Public health Direction and Biodonostia- CIBERESP, Basque Regional Health Department, San Sebastian, Spain.
19
Public Health Directorate, Asturias, Spain.
20
Department of odontology, Umeå University, Sweden.
21
Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Sweden.
22
Department of Clinical Sciences in Malmö, Nutrition Epidemiology, Lund University, Malmö, Sweden.
23
The Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
24
Clinical Gerontology Unit, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom.
25
MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
26
Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom; Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.

Abstract

BACKGROUND:

Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

METHODS:

Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow-up, age, energy, alcohol, smoking status, physical activity, and region.

RESULTS:

In women, doubling elaidic acid was associated with a decreased risk of weight loss (odds ratio (OR) = 0.69, 95% confidence interval (CI) = 0.55-0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5-year follow-up (OR = 1.23, 95% CI = 0.97-1.56, p = 0.082) (p-trend<.0001). In men, a trend was observed for doubling elaidic acid level and risk of weight loss (OR = 0.82, 95% CI = 0.66-1.01, p = 0.062) while no significant association was found with risk of weight gain during the 5-year follow-up (OR = 1.08, 95% CI = 0.88-1.33, p = 0.454). No association was found for saturated and cis-monounsaturated fatty acids.

CONCLUSIONS:

These data suggest that a high intake of industrial trans fatty acids may decrease the risk of weight loss, particularly in women. Prevention of obesity should consider limiting the consumption of highly processed foods, the main source of industrially-produced trans fatty acids.

PMID:
25675445
PMCID:
PMC4326417
DOI:
10.1371/journal.pone.0118206
[Indexed for MEDLINE]
Free PMC Article

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