Format

Send to

Choose Destination
Endocr Rev. 2015 Apr;36(2):149-73. doi: 10.1210/er.2014-1063. Epub 2015 Feb 12.

Glucose homeostasis during short-term and prolonged exposure to high altitudes.

Author information

1
Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.

Abstract

Most of the literature related to high altitude medicine is devoted to the short-term effects of high-altitude exposure on human physiology. However, long-term effects of living at high altitudes may be more important in relation to human disease because more than 400 million people worldwide reside above 1500 m. Interestingly, individuals living at higher altitudes have a lower fasting glycemia and better glucose tolerance compared with those who live near sea level. There is also emerging evidence of the lower prevalence of both obesity and diabetes at higher altitudes. The mechanisms underlying improved glucose control at higher altitudes remain unclear. In this review, we present the most current evidence about glucose homeostasis in residents living above 1500 m and discuss possible mechanisms that could explain the lower fasting glycemia and lower prevalence of obesity and diabetes in this population. Understanding the mechanisms that regulate and maintain the lower fasting glycemia in individuals who live at higher altitudes could lead to new therapeutics for impaired glucose homeostasis.

PMID:
25675133
PMCID:
PMC4399271
DOI:
10.1210/er.2014-1063
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center