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Cell Host Microbe. 2015 Feb 11;17(2):141-2. doi: 10.1016/j.chom.2015.01.008.

Double trouble: HIV latency and CTL escape.

Author information

  • 1Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA 90095, USA.
  • 2Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA. Electronic address: jzack@ucla.edu.

Abstract

HIV can enter a state of latency that allows it to persist for decades in antiretroviral drug-treated patients. In a recent Nature paper, Deng et al. (2015) show that this latent reservoir also contains a large number of cytotoxic T lymphocyte escape mutants, presenting another challenge to HIV cure efforts.

PMID:
25674977
PMCID:
PMC4375954
DOI:
10.1016/j.chom.2015.01.008
[PubMed - indexed for MEDLINE]
Free PMC Article
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