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Sci Rep. 2015 Feb 12;5:8487. doi: 10.1038/srep08487.

Association between levonorgestrel emergency contraception and the risk of ectopic pregnancy: a multicenter case-control study.

Author information

1
Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China.
2
Department of Obstetrics and Gynecology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
3
Department of Obstetrics and Gynecology, Songjiang Central Hospital, Shanghai 201600, China.
4
Department of Obstetrics and Gynecology, Songjiang Maternity and Child Health Hospital, Shanghai 201620, China.
5
Department of Obstetrics and Gynecology, Minhang Central Hospital, Shanghai 201100, China.
6
Shanghai Institute of Planned Parenthood Research, Shanghai 200030, China.
7
Department of Reproductive Medicine, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China.

Abstract

Cases of ectopic pregnancy (EP) following levonorgestrel emergency contraception (LNG-EC) failure have been reported continuously, but whether there is an association between EP risk and LNG-EC is unclear. We concluded a case-control study to explore this association by recruiting 2,411 EP patients as case group, and 2,416 women with intrauterine pregnancy and 2,419 non-pregnant women as control groups. Odds ratios (ORs) and their 95% confidential intervals (CIs) were calculated and adjusted for potential confounding factors. Previous use of LNG-EC was not correlated with the EP. Compared to women who did not use contraceptives, current use of LNG-EC reduced the risk for intrauterine pregnancy (Adjusted OR [AOR] = 0.20, 95%CI: 0.14-0.27), but did not increase the risk for EP (AOR2 = 1.04, 95%CI: 0.76-1.42). Furthermore, compared to women who did not have further act of intercourse, women with unprotected further act of intercourse were at a higher risk of EP (AOR1 = 2.35, 95%CI: 1.17-4.71), and women with repeated use of LNG-EC for further intercourse during the same cycle was also associated with a higher risk for EP (AOR1 = 3.08, 95%CI: 1.09-8.71; AOR2 = 2.49, 95%CI: 1.00-6.19). A better understanding of the risk of EP following LNG-EC failure can optimize LNG-EC use and thus reduce the risk of EP.

PMID:
25674909
PMCID:
PMC4325579
DOI:
10.1038/srep08487
[Indexed for MEDLINE]
Free PMC Article

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