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Clin Infect Dis. 2015 Jun 1;60(11):e80-9. doi: 10.1093/cid/civ065. Epub 2015 Feb 11.

Prevalence and Incidence of Respiratory Syncytial Virus and Other Respiratory Viral Infections in Children Aged 6 Months to 10 Years With Influenza-like Illness Enrolled in a Randomized Trial.

Author information

1
Murdoch Children's Research Institute and Melbourne School of Population and Global Health, University of Melbourne, Carlton, Victoria, Australia.
2
Department of Health, Research Institute for Tropical Medicine, Alabang, Muntinlupa City, Philippines.
3
Centro de Estudios en Infectologia Pediatrica, Cali, Colombia.
4
Pediatric Infectious Diseases, Department of Pediatrics, Universidade Federal de São Paulo, Brazil.
5
Instituto Costarricense de Investigaciones Clínicas, San José, Costa Rica.
6
National Institute of Public Health of Mexico, Cuernavaca Morelos.
7
Infectious Diseases Unit, Department of Pediatrics, Phramongkutklao Hospital, Thailand.
8
Instituto Nacional de Pediatría de Mexico.
9
Servicios Medicos Universidad Autonoma de Nuevo Leon, Monterrey.
10
Hospital General de Durango, Mexico.
11
Department of Pediatrics, Faculdade de Ciências Médicas da Santa Casa de São Paulo and Associação Fundo de Incentivo à Pesquisa, Brazil.
12
National Healthcare Group Polyclinics, Singapore.
13
GSK Vaccines, Wavre, Belgium.
14
GSK Vaccines, King of Prussia, Pennsylvania.
15
GSK Vaccines, Rixensart, Belgium.

Abstract

BACKGROUND:

The high burden of respiratory syncytial virus (RSV)-associated morbidity and mortality makes vaccine development a priority.

METHODS:

As part of an efficacy trial of pandemic influenza vaccines (NCT01051661), RSV epidemiology in healthy children aged 6 months to <10 years at first vaccination with influenza-like illness (ILI) was evaluated in Australia, Brazil, Colombia, Costa Rica, Mexico, the Philippines, Singapore, and Thailand between February 2010 and August 2011. Active surveillance for ILI was conducted for approximately 1 year, with nasal and throat swabs analyzed by polymerase chain reaction. The prevalence and incidence of RSV among ILI episodes were calculated.

RESULTS:

A total of 6266 children were included, of whom 2421 experienced 3717 ILI episodes with a respiratory sample available. RSV was detected for 359 ILI episodes, a prevalence of 9.7% (95% confidence interval: 8.7-10.7). The highest prevalence was in children aged 12-23 or 24-35 months in all countries except the Philippines, where it was in children aged 6-11 months. The incidence of RSV-associated ILI was 7.0 (6.3-7.7) per 100 person-years (PY). Eighty-eight ILI episodes resulted in hospitalization, of which 8 were associated with RSV (prevalence 9.1% [4.0-17.1]; incidence 0.2 [0.1-0.3] per 100 PY). The incidence of RSV-associated ILI resulting in medical attendance was 6.0 (5.4-6.7) per 100 PY. RSV B subtypes were observed more frequently than A subtypes.

CONCLUSIONS:

Active surveillance demonstrated the considerable burden of RSV-associated illness that would not be identified through hospital-based surveillance, with a substantial part of the burden occurring in older infants and children.

KEYWORDS:

ILI; RSV; children; incidence; prevalence

PMID:
25673560
PMCID:
PMC4429758
DOI:
10.1093/cid/civ065
[Indexed for MEDLINE]
Free PMC Article

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