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Nat Rev Cancer. 2015 Apr;15(4):248-54. doi: 10.1038/nrc3896. Epub 2015 Feb 12.

Triple-negative breast cancer in African-American women: disparities versus biology.

Author information

1
1] Duke University, Durham, North Carolina 27710, USA. [2].
2
1] University of Tennessee Health Science Center, Memphis, Tennessee 90095, USA. [2].
3
1] Winship Cancer Institute, Emory University and Grady Memorial Hospital, Atlanta, Georgia 30322, USA. [2].

Abstract

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects BRCA1 mutation carriers and young women of African origin. There is evidence that African-American women with TNBC have worse clinical outcomes than women of European descent. However, it is unclear whether survival differences persist after adjusting for disparities in access to health-care treatment, co-morbid disease and income. It remains controversial whether TNBC in African-American women is a molecularly distinct disease or whether African-American women have a higher incidence of aggressive biology driven by disparities: there is evidence in support of both. Understanding the relative contributions of biology and disparities is essential for improving the poor survival rate of African-American women with TNBC.

PMID:
25673085
PMCID:
PMC5470637
DOI:
10.1038/nrc3896
[Indexed for MEDLINE]
Free PMC Article

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