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Expert Rev Clin Pharmacol. 2015 Mar;8(2):201-10. doi: 10.1586/17512433.2015.1012494. Epub 2015 Feb 12.

How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease.

Author information

1
Medical Research Service, Veterans Hospital, Tampa, 33612 FL, USA.

Abstract

We have provided a critical assessment of research on the reduction of cholesterol levels by statin treatment to reduce cardiovascular disease. Our opinion is that although statins are effective at reducing cholesterol levels, they have failed to substantially improve cardiovascular outcomes. We have described the deceptive approach statin advocates have deployed to create the appearance that cholesterol reduction results in an impressive reduction in cardiovascular disease outcomes through their use of a statistical tool called relative risk reduction (RRR), a method which amplifies the trivial beneficial effects of statins. We have also described how the directors of the clinical trials have succeeded in minimizing the significance of the numerous adverse effects of statin treatment.

KEYWORDS:

absolute risk; adverse effects; cancer; dementia; hypercholesterolemia; myositis; relative risk; statins; trials

PMID:
25672965
DOI:
10.1586/17512433.2015.1012494
[Indexed for MEDLINE]

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