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Sci Rep. 2015 Feb 12;5:8423. doi: 10.1038/srep08423.

The epileptic thalamocortical network is a macroscopic self-sustained oscillator: evidence from frequency-locking experiments in rat brains.

Author information

1
Neuroscience &Mental Health Programme and Division of Neurology, Hospital for Sick Children; Institute of Medical Science and Department of Paediatrics, University of Toronto, Toronto, Canada.
2
INSERM-CEA Cognitive Neuroimaging Unit - Point Courrier 156F-91191 Gif SUR YVETTE Cedex, France.
3
Department of Physics and Astronomy, University of Potsdam, Potsdam, Germany.

Abstract

The rhythmic activity observed in nervous systems, in particular in epilepsies and Parkinson's disease, has often been hypothesized to originate from a macroscopic self-sustained neural oscillator. However, this assumption has not been tested experimentally. Here we support this viewpoint with in vivo experiments in a rodent model of absence seizures, by demonstrating frequency locking to external periodic stimuli and finding the characteristic Arnold tongue. This result has important consequences for developing methods for the control of brain activity, such as seizure cancellation.

PMID:
25672543
PMCID:
PMC4325330
DOI:
10.1038/srep08423
[Indexed for MEDLINE]
Free PMC Article

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