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Invest Ophthalmol Vis Sci. 2015 Feb 10;56(3):1842-9. doi: 10.1167/iovs.14-15644.

Photoreceptor regulation of spatial visual behavior.

Author information

1
Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States Burke Medical Research Institute, White Plains, New York, United States.
2
Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States.
3
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
4
Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

Abstract

PURPOSE:

To better understand how photoreceptors and their circuits support luminance-dependent spatial visual behavior.

METHODS:

Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity.

RESULTS:

The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod-cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone-like spatial visual function, but only when cones were genetically maintained in a physiological dark state.

CONCLUSIONS:

The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems.

KEYWORDS:

cone; ipRGC; melanopsin; mesopic; optokinetic tracking; photopic; photoreceptors; rod; scotopic; spatial vision; visual behavior

PMID:
25670495
DOI:
10.1167/iovs.14-15644
[Indexed for MEDLINE]

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