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Cancer Cell. 2015 Feb 9;27(2):163-75. doi: 10.1016/j.ccell.2015.01.001.

Emerging strategies for treating brain metastases from breast cancer.

Author information

1
Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
2
Edwin L. Steele Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: jain@steele.mgh.harvard.edu.

Abstract

Brain metastasis is an end stage in breast cancer progression. Traditional treatment options have minimal efficacy, and overall survival is on the order of months. The incidence of brain metastatic disease is increasing with the improved management of systemic disease and prolongation of survival. Unfortunately, the targeted therapies that control systemic disease have diminished efficacy against brain lesions. There are reasons to be optimistic, however, as emerging therapies have shown promise in preclinical and early clinical settings. This review discusses recent advances in breast cancer brain metastasis therapy and potential approaches for successful treatment.

PMID:
25670078
PMCID:
PMC4325273
DOI:
10.1016/j.ccell.2015.01.001
[Indexed for MEDLINE]
Free PMC Article

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