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Cancer Cell. 2015 Feb 9;27(2):156-7. doi: 10.1016/j.ccell.2015.01.007.

Reactive oxygen species in cancer: a dance with the devil.

Author information

1
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: p-schumacker@northwestern.edu.

Abstract

Reactive oxygen species (ROS) can initiate cancer, but oxidant generation in tumors leaves them vulnerable to further stresses. In this issue of Cancer Cell, Harris and colleagues show that augmenting oxidant stress in normal cells limits tumor initiation and progression. Hence, strategic targeting of antioxidant systems may undermine survival of new tumor cells.

PMID:
25670075
DOI:
10.1016/j.ccell.2015.01.007
[Indexed for MEDLINE]
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