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J Neuroimmunol. 2015 Feb 15;279:7-10. doi: 10.1016/j.jneuroim.2014.12.017. Epub 2014 Dec 19.

Serum cytokine and chemokine profiles in patients with chronic inflammatory demyelinating polyneuropathy.

Author information

1
Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan; Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan. Electronic address: beppu@chiba-u.jp.
2
Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
3
Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.

Abstract

To identify serum cytokine networks specific to chronic inflammatory demyelinating polyneuropathy (CIDP), serum samples of two subgroups (18 patients with typical CIDP and 12 patients with multifocal acquired demyelinating sensory and motor neuropathy [MADSAM]) were analyzed with multiplex magnetic bead-based cytokine assay. TNF-α, HGF, MIP-1β and IL-1β levels were significantly higher in total CIDP patients than in normal controls. Of these, HGF levels were elevated in typical CIDP patients, but not in MADSAM patients. Patients with high HGF levels showed good responses to steroid treatment. Different cytokine profiles among the CIDP subtypes presumably reflect differences in pathophysiology.

KEYWORDS:

Chronic inflammatory demyelinating polyneuropathy; Cytokine; HGF; IL-1β; MIP-1α; MIP-1β; TNF-α

PMID:
25669993
DOI:
10.1016/j.jneuroim.2014.12.017
[Indexed for MEDLINE]

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