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J Am Chem Soc. 2015 Feb 25;137(7):2460-3. doi: 10.1021/ja5130012. Epub 2015 Feb 12.

Catalytic C-H imidation of aromatic cores of functional molecules: ligand-accelerated Cu catalysis and application to materials- and biology-oriented aromatics.

Author information

1
Institute of Transformative Bio-Molecules (WPI-ITbM) and Graduate School of Science, Nagoya University , Chikusa, Nagoya 464-8602, Japan.

Abstract

Versatile imidation of aromatic C-H bonds was accomplished. In the presence of copper bromide and 6,6'-dimethyl-2,2'-bipyridyl, a range of aromatics, such as polycyclic aromatic hydrocarbons, aromatic bowls, porphyrins, heteroaromatics, and natural products, can be imidated by N-fluorobenzenesulfonimide. A dramatic ligand-accelerated copper catalysis and an interesting kinetic profile were uncovered.

PMID:
25669319
DOI:
10.1021/ja5130012
[Indexed for MEDLINE]

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