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Clin Appl Thromb Hemost. 2015 Oct;21(7):597-602. doi: 10.1177/1076029615571630. Epub 2015 Feb 10.

Factoring in Factor VIII With Acute Ischemic Stroke.

Author information

1
Department of Neurology, Tulane Stroke Research Program, Tulane Medical Center, New Orleans, LA, USA.
2
Department of Neurology, Tulane Stroke Research Program, Tulane Medical Center, New Orleans, LA, USA Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA.
3
Geriatric Research Education and Clinical Center (GRECC), Birmingham VA Medical Center, Birmingham, AL, USA Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
4
Department of Neurology, Gertrude Sergievsky Center, Columbia University, New York, NY, USA.
5
Department of Neurology, Tulane Stroke Research Program, Tulane Medical Center, New Orleans, LA, USA smartin2@tulane.edu.

Abstract

There is growing research interest into the etiologies of cryptogenic stroke, in particular as it relates to hypercoagulable states. An elevation in serum levels of the procoagulant factor VIII is recognized as one such culprit of occult cerebral infarctions. It is the objective of the present review to summarize the molecular role of factor VIII in thrombogenesis and its clinical use in the diagnosis and prognosis of acute ischemic stroke. We also discuss the utility of screening for serum factor VIII levels among patients at risk for, or those who have experienced, ischemic stroke.

KEYWORDS:

factor viii; hypercoagulability; stroke; thrombosis; von Willebrand factor

PMID:
25669199
PMCID:
PMC4948295
DOI:
10.1177/1076029615571630
[Indexed for MEDLINE]
Free PMC Article

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