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Nature. 1989 May 25;339(6222):280-6.

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity.

Author information

1
Department of Biochemistry and Biophysics, School of Medicine, University of California, San Francisco 94143-0448.

Abstract

We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.

PMID:
2566918
DOI:
10.1038/339280a0
[Indexed for MEDLINE]

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