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J Nat Prod. 2015 Mar 27;78(3):493-9. doi: 10.1021/np5009762. Epub 2015 Feb 10.

Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta.

Author information

1
†Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92037, United States.
2
§Environmental Systems Program, University of California-San Diego, La Jolla, California 92093, United States.
3
∥Department of Statistical Modeling, St. Petersburg State University, St. Petersburg, Russia.
4
∇Algorithmic Biology Laboratory, St. Petersburg Academic University, St. Petersburg, Russia.
5
□The Center for Algorithmic Biotechnology, St. Petersburg State University, St. Petersburg, Russia.
6
#Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, California 92093, United States.

Abstract

Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.

PMID:
25668560
PMCID:
PMC5065018
DOI:
10.1021/np5009762
[Indexed for MEDLINE]
Free PMC Article

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