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Anticancer Res. 2015 Feb;35(2):1171-80.

Vitamin D levels and dietary intake among patients with benign soft tissue tumors and sarcomas.

Author information

1
Department of Radiation Biology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway astaj@rr-research.no.
2
Department of Radiation Biology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
3
Department of Paediatrics, Haukeland University Hospital, Bergen, Norway Department of Clinical Science, University of Bergen, Norway.
4
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
5
Department of Radiation Biology, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway Institute of Physics, University of Oslo, Oslo, Norway.

Abstract

BACKGROUND:

Calcitriol [1,25(OH)2D] is hypothesized to lower the risk of cancer via binding to the vitamin D receptor (VDR). VDRs are also found in benign and malignant cells of mesenchymal origin. To our knowledge, vitamin D levels and dietary intake have not been previously evaluated in patients newly diagnosed with benign and malignant mesenchymal tumors.

PATIENTS AND METHODS:

Forty-eight patients with benign soft tissue tumors and 25 patients with sarcoma had their serum 25-hydroxyvitamin D [25(OH)D], 1,25(OH)2D and parathyroid hormone levels measured, vitamin D intake scored and body mass index [BMI] calculated.

RESULTS:

Vitamin D deficiency [25(OH)D level<50 nmol/l] was observed in 19% and 28% of patients with benign tumor and sarcoma, respectively.

CONCLUSION:

Serum 25(OH)D, 1,25(OH)2D and parathyroid hormone concentrations, BMI and daily vitamin D intake did not differ significantly between the two groups of patients. Higher vitamin D intake or UV exposure is needed to ensure that all patients achieve sufficient vitamin D levels.

KEYWORDS:

1,25-dihydroxyvitamin D; 25-Hydroxyvitamin D; benign soft tissue tumor; daily vitamin D intake; parathyroid hormone; sarcoma

PMID:
25667508
[Indexed for MEDLINE]

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