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Anticancer Res. 2015 Feb;35(2):1153-60.

25-hydroxyvitamin D and breast cancer, colorectal cancer, and colorectal adenomas: case-control versus nested case-control studies.

Author information

1
Sunlight, Nutrition, and Health Research Center, San Francisco, CA, U.S.A. wbgrant@infionline.net/www.sunarc.org.

Abstract

BACKGROUND:

Existing literature includes concerns regarding reliability of case-control studies of breast cancer incidence with respect to 25-hydroxyvitamin D (25(OH)D) concentrations. For breast cancer, only case-control studies consistently find inverse correlations between 25(OH)D and breast cancer. However, for colorectal cancer, nested case-control studies find significant inverse correlations with respect to 25(OH)D concentrations at baseline for mean follow-up times of 7 years.

MATERIALS AND METHODS:

This is a review of results currently existing in literature.

RESULTS:

I provide evidence that 25(OH)D concentration values are only useful for short follow-up times for breast cancer since it develops rapidly. To support the robust nature of breast cancer case-control studies, I show that results from 11 studies from seven countries align in a robust power-law fit to the odds ratio versus mean 25(OH)D concentrations.

CONCLUSION:

Case-control studies of breast cancer incidence rates provide reliable results.

KEYWORDS:

Breast cancer; case-control study; colorectal adenoma; colorectal cancer; nested case-control study; vitamin D

PMID:
25667506
[Indexed for MEDLINE]

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