Format

Send to

Choose Destination
Reprod Sci. 2015 Aug;22(8):942-7. doi: 10.1177/1933719115570900. Epub 2015 Feb 8.

Effects of Resveratrol on Ovarian Morphology, Plasma Anti-Mullerian Hormone, IGF-1 Levels, and Oxidative Stress Parameters in a Rat Model of Polycystic Ovary Syndrome.

Author information

1
Department of Obstetrics and Gynecology, Ege University, Izmir, Turkey.
2
Department of Obstetrics and Gynecology, Dokuz Eylul University, Izmir, Turkey Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey nuri-yildirim@hotmail.com nuri.yildirim@deu.edu.tr.
3
Department of Physiology, Ege University, Izmir, Turkey.
4
Department of Histology and Embryology, Ege University, Izmir, Turkey.

Abstract

OBJECTIVE:

To evaluate the effects of resveratrol in a rat model of polycystic ovarian syndrome (PCOS).

STUDY DESIGN:

After PCOS model was formed by subcutaneous dihydrotestosterone pellets, rats were randomly divided into 2 groups. The first group (n = 7) was treated with 1 mL/kg/d isotonic saline and the second group (n = 7) was treated with 10 mg/kg/d resveratrol. Seven rats were taken as controls without any medication.

RESULTS:

Our results showed (1) significant reduction in the number of antral follicle counts (P < .01); (2) significantly decreased plasma anti-Mullerian hormone and insulin-like growth factor 1 levels (P < .01 and P < .05, respectively); (3) significantly lower superoxide dismutase activity (P < .05); and (4) significantly increased glutathione peroxidase content (P < .01) following resveratrol treatment.

CONCLUSION:

Resveratrol appears to be effective in the treatment of PCOS due to its antioxidant properties. Future clinical studies with different dosages might provide useful implementations to our practice.

KEYWORDS:

anti-Mullerian hormone; oxidative stress; polycystic ovary syndrome; rat model; resveratrol

PMID:
25667201
DOI:
10.1177/1933719115570900
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center