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Gastroenterol Clin North Am. 2015 Mar;44(1):169-84. doi: 10.1016/j.gtc.2014.11.013. Epub 2014 Dec 29.

Gastric arrhythmias in gastroparesis: low- and high-resolution mapping of gastric electrical activity.

Author information

1
Department of Surgery, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
2
Division of Gastroenterology, GI Motility Clinic, University of Louisville, 220 Abraham Flexner Way, Suite 300, Louisville, KY 40202, USA. Electronic address: thomas.abell@louisville.edu.

Abstract

Gastric arrhythmias occur in gastroparesis but their significance is debated. An improved understanding is currently emerging, including newly-defined histopathologic abnormalities in gastroparesis. In particular, the observation that interstitial cells of Cajal are depleted and injured provides mechanisms for arrhythmogenesis in gastroparesis. Electrogastrography has been the dominant clinical method of arrhythmia analysis, but is limited by summative nature, low signal quality, and incomplete sensitivity and specificity. Recently, high-resolution (HR; multi-electrode) mapping has emerged, providing superior spatial data on arrhythmic patterns and mechanisms. However, HR mapping is invasive, and low-resolution approaches are being assessed as bridging techniques until endoscopic mapping is achieved.

KEYWORDS:

Electrogastrography; Interstitial cells of Cajal; Slow wave; Tachygastria

PMID:
25667031
PMCID:
PMC4323584
DOI:
10.1016/j.gtc.2014.11.013
[Indexed for MEDLINE]
Free PMC Article

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