Factors influencing culture positivity in pyogenic vertebral osteomyelitis patients with prior antibiotic exposure

Antimicrob Agents Chemother. 2015 Apr;59(4):2470-3. doi: 10.1128/AAC.04949-14. Epub 2015 Feb 9.

Abstract

We conducted a retrospective cohort study to evaluate factors influencing tissue culture positivity in patients with pyogenic vertebral osteomyelitis exposed to antibiotics before diagnosis. Tissue culture was positive in 48.3% (28/58) of the patients, and the median antibiotic-free period was 1.5 days (range, 0.7 to 5.7 days). In a multivariate analysis, a higher C-reactive protein (CRP) level (adjusted odds ratio [aOR], 1.18; 95% confidence interval, 1.07 to 1.29) and open surgical biopsy (aOR, 6.33; 95% confidence interval, 1.12 to 35.86) were associated with tissue culture positivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Infections / drug therapy
  • Biopsy
  • C-Reactive Protein / metabolism
  • Cohort Studies
  • Female
  • Fever / complications
  • Humans
  • Leukocyte Count
  • Male
  • Middle Aged
  • Osteomyelitis / microbiology*
  • Retrospective Studies
  • Spinal Diseases / microbiology*
  • Spine / microbiology

Substances

  • Anti-Bacterial Agents
  • C-Reactive Protein