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Hum Immunol. 2015 Mar;76(2-3):142-5. doi: 10.1016/j.humimm.2015.01.010. Epub 2015 Feb 7.

HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study.

Author information

1
Children's Hospital of Oakland Research Institute, Oakland, CA 94609, USA.
2
Jules Stein Eye Institute and the UCLA Department of Ophthalmology, Los Angeles, CA 90095, USA.
3
Atreca, Inc., San Carlos, CA 94070, USA.
4
California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA. Electronic address: gtranah@sfcc-cpmc.net.

Abstract

Multiple lines of evidence support an immunologic basis and genetic disposition for the development of age-related macular degeneration (AMD). Comprehensive human leukocyte antigens (HLA) class II typing at four loci (DRB1, DQA1, DQB1, and DPB1) was assessed using next generation sequencing methods and tested for association with age-related macular degeneration (AMD) in a case-control study of 456 AMD cases and 499 controls from the population-based Study of Osteoporotic Fractures (SOF) cohort. No statistically significant associations were identified for any of the class II loci and a previously identified association between DRB1*13:01 was not replicated in this dataset. These results reported here suggest that common HLA class II genetic variation does not contribute to AMD disease risk.

KEYWORDS:

AMD; Age related macular degeneration; Class II; HLA; Next generation sequencing

PMID:
25665771
PMCID:
PMC4476503
DOI:
10.1016/j.humimm.2015.01.010
[Indexed for MEDLINE]
Free PMC Article

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