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Channels (Austin). 2015;9(1):14-20. doi: 10.4161/19336950.2014.981439.

A new genetic model for calcium induced autophagy and ER-stress in Drosophila photoreceptor cells.

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a Department of Medical Neurobiology ; Institute for Medical Research Israel-Canada (IMRIC) and the Edmond and Lily Safra Center for Brain Sciences (ELSC); Faculty of Medicine; The Hebrew University ; Jerusalem , Israel.


Cytoplasmic Ca2+ overload is known to trigger autophagy and ER-stress. Furthermore, ER-stress and autophagy are commonly associated with degenerative pathologies, but their role in disease progression is still a matter of debate, in part, owing to limitations of existing animal model systems. The Drosophila eye is a widely used model system for studying neurodegenerative pathologies. Recently, we characterized the Drosophila protein, Calphotin, as a cytosolic immobile Ca2+ buffer, which participates in Ca2+ homeostasis in Drosophila photoreceptor cells. Exposure of calphotin hypomorph flies to continuous illumination, which induces Ca2+ influx into photoreceptor cells, resulted in severe Ca2+-dependent degeneration. Here we show that this degeneration is autophagy and ER-stress related. Our studies thus provide a new model in which genetic manipulations trigger changes in cellular Ca2+ distribution. This model constitutes a framework for further investigations into the link between cytosolic Ca2+, ER-stress and autophagy in human disorders and diseases.


Drosophila; ER-stress; Transient receptor potential- TRP; autophagy; calcium homeostasis; calphotin; calphotin hypomorph- Cpn1%; calphotin- Cpn; dMoesin- Moe; photoreceptor cells

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