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J Clin Invest. 2015 Mar 2;125(3):908-17. doi: 10.1172/JCI76309. Epub 2015 Feb 9.

Gut chemosensing mechanisms.

Abstract

The enteroendocrine system is the primary sensor of ingested nutrients and is responsible for secreting an array of gut hormones, which modulate multiple physiological responses including gastrointestinal motility and secretion, glucose homeostasis, and appetite. This Review provides an up-to-date synopsis of the molecular mechanisms underlying enteroendocrine nutrient sensing and highlights our current understanding of the neuro-hormonal regulation of gut hormone secretion, including the interaction between the enteroendocrine system and the enteric nervous system. It is hoped that a deeper understanding of how these systems collectively regulate postprandial physiology will further facilitate the development of novel therapeutic strategies.

PMID:
25664852
PMCID:
PMC4362249
DOI:
10.1172/JCI76309
[Indexed for MEDLINE]
Free PMC Article
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