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Int J Exp Pathol. 2015 Apr;96(2):73-80. doi: 10.1111/iep.12114. Epub 2015 Feb 9.

Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin.

Author information

1
Department of Pharmacognosy, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
2
Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
3
Department of Toxicology, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
4
Department of Pathology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
5
Department of Microscopic Morphology/Histology, Angiogenesis Research Center, University of Medicine and Pharmacy 'Victor Babes', Timisoara, Romania.
6
Pharmazentrum Frankfurt/Center for Drug Research, Development, and Safety, Clinic of J. W. Goethe University, Frankfurt, Germany.

Abstract

Transplantable murine melanomas are well-established models for the study of experimental cancer therapies. The aim of this study was to explore the behaviour of four different B16 murine melanoma cell sublines after inoculation into C57BL/6J mice; and, more specifically to analyse skin changes, with respect to two specific parameters: clinical (tumour volume, melanin amount, erythema) and histological (H & E, S100, VEGF expression). Both non-invasive and invasive analysis showed that B164A5 is the most aggressive melanoma cell line for C57BL/6J's skin, followed by B16F10 and then by diminished aggressive growth pattern by the B16GMCSF and B16FLT3 cell lines.

KEYWORDS:

B164A5; B16F10; B16FLT3; B16GMCSF; C57BL/6J

PMID:
25664478
PMCID:
PMC4459798
DOI:
10.1111/iep.12114
[Indexed for MEDLINE]
Free PMC Article

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