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Med J Islam Repub Iran. 2014 Sep 20;28:100. eCollection 2014.

Relationship between serum levels of fetuin-A with apo-A1, apo-B100, body composition and insulin resistance in patients with type 2 diabetes.

Author information

1
1. PhD. Professor of Nutrition, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. shidfar.f@iums.ac.ir.
2
2. PhD, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. zarrati_ms@yahoo.com.
3
3. Professor of Endocrinology, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. khamseh.m@iums.ac.ir.
4
4. Master, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. neda.hag@gmail.com.
5
5. Master, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. ali.rostami.nut@gmail.com.
6
6. Master, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. h.z.7025@gmail.com.

Abstract

BACKGROUND:

Some results exist on fetuin-A as marker for vascular disease in type 2diabetes. We examined the relationship between serum fetuin-A with some factors, in patients with type 2 diabetes mellitus (T2DM).

METHODS:

From October 2012 to June 2013, a total of 131 T2DM patients were recruited and evaluated for various parameters including HOMA-IR, Apo-A1, Apo-B100, body fat percentage and waist circumference. Serum fetuin-A levels were measured by enzyme-linkedimmunosorbent assay (ELISA), and Serum glucose with a Cobas MIRA analyzer by enzymatic method. Apo-B100 and apo-A1 were measured by immunoturbidimetry with a Cobas MIRA analyzer. HOMA-IR was calculated by the following formula: [fasting insulin (uIU/mL) × fasting blood glucose (mmol/L)]/22.5.

RESULTS:

The mean levels of HOMA-IR were significantly increased progressively across fetuin-A tertiles (p for trend=0.04) in women but not men. Fetuin-A had just a significant positive correlation with Apo- A1(r=0.22, p=0.02).

CONCLUSION:

This present study showed that levels of serum fetuin-A are significantly associated with insulin resistance in women with T2DM.

KEYWORDS:

Apo-A1; Apo-B100; Body Fat Percentage; Fetuin-A; Insulin Resistance; Type 2 Diabetes

PMID:
25664301
PMCID:
PMC4301224

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