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Biochim Biophys Acta. 2015 Sep;1853(9):2012-7. doi: 10.1016/j.bbamcr.2015.01.022. Epub 2015 Feb 4.

Calcium signaling at ER membrane contact sites.

Author information

1
UCL Institute of Ophthalmology, London, UK.
2
Department of Cell and Developmental Biology, UCL, London, UK.
3
UCL Institute of Ophthalmology, London, UK. Electronic address: e.eden@ucl.ac.uk.

Abstract

Communication between organelles is a necessary consequence of intracellular compartmentalization. Membrane contact sites (MCSs) are regions where the membranes of two organelles come into close apposition allowing exchange of small molecules and ions including Ca²⁺. The ER, the cell's major Ca²⁺ store, forms an extensive and dynamic network of contacts with multiple organelles. Here we review established and emerging roles of ER contacts as platforms for Ca²⁺ exchange and further consider a potential role for Ca²⁺ in the regulation of MCS formation. We additionally discuss the challenges associated with the study of MCS biology and highlight advances in microscopy-based solutions. This article is part of a Special Issue entitled: 13th European Symposium on Calcium.

KEYWORDS:

Ca2+ exchange; Calcium; ER; Membrane contact sites (MCSs)

PMID:
25662816
DOI:
10.1016/j.bbamcr.2015.01.022
[Indexed for MEDLINE]
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