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Addict Behav. 2015 Jun;45:119-23. doi: 10.1016/j.addbeh.2015.01.013. Epub 2015 Jan 23.

Cognitive performance in a placebo-controlled pharmacotherapy trial for youth with marijuana dependence.

Author information

1
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, 125 Doughty Street, Suite 190, MSC 861, Charleston, SC 29425, United States. Electronic address: rotena@musc.edu.
2
Medical University of South Carolina, Department of Public Health Sciences, 135 Cannon Street, MSC 835, Charleston, SC 29425, United States.
3
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, 125 Doughty Street, Suite 190, MSC 861, Charleston, SC 29425, United States.

Abstract

BACKGROUND:

Adolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance.

METHODS:

This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery.

RESULTS:

Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores.

CONCLUSIONS:

These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.

KEYWORDS:

Adolescent; Cognition; Cognitive performance; Marijuana; Memory; Youth

PMID:
25661990
PMCID:
PMC4373963
DOI:
10.1016/j.addbeh.2015.01.013
[Indexed for MEDLINE]
Free PMC Article

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