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Autoimmun Rev. 2015 Jun;14(6):555-63. doi: 10.1016/j.autrev.2015.01.017. Epub 2015 Feb 3.

Autoantibodies 2015: From diagnostic biomarkers toward prediction, prognosis and prevention.

Author information

1
Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: jan.damoiseaux@mumc.nl.
2
Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; Immunology Division, Fleury Medicine and Health Laboratories, Sao Paulo, Brazil.
3
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
4
The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.

Abstract

At the 12th International Workshop on Autoantibodies and Autoimmunity (IWAA), organized in August 2014 in Sao Paulo, Brazil, more than 300 autoimmunologists gathered to discuss the status of many novel autoantibodies in clinical practice, and to envisage additional value of autoantibodies in terms of prediction, prognosis and prevention of autoimmune diseases. Two separate workshops were dedicated to standardization and harmonization of autoantibody testing and nomenclature: International Autoantibody Standardization (IAS) and International Consensus on ANA Patterns (ICAP). It was apparent to all in attendance that the discovery and elucidation of novel autoantibodies did not slow down, but that multiple challenges lay ahead of us in order to apply these discoveries to effective and efficient clinical practice. Importantly, this requires optimal bidirectional communication between clinicians and laboratory specialists, as well as close collaboration with the diagnostic industry. This paper is a report on the 12th IWAA in combination with a review of the recent developments in the field of autoantibodies.

KEYWORDS:

Autoantibodies; Diagnosis; Harmonization; Standardization

PMID:
25661979
DOI:
10.1016/j.autrev.2015.01.017
[Indexed for MEDLINE]

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