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Pathobiol Aging Age Relat Dis. 2015 Feb 5;5:25592. doi: 10.3402/pba.v5.25592. eCollection 2015.

Zinc, aging, and immunosenescence: an overview.

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Department of Internal Medicine and Geriatrics, Academic Hospital "Dr. Gustavo Aldereguía Lima", Cienfuegos, Cuba;


Zinc plays an essential role in many biochemical pathways and participates in several cell functions, including the immune response. This review describes the role of zinc in human health, aging, and immunosenescence. Zinc deficiency is frequent in the elderly and leads to changes similar to those that occur in oxidative inflammatory aging (oxi-inflamm-aging) and immunosenescence. The possible benefits of zinc supplementation to enhance immune function are discussed.


aging; immunosenescence; zinc

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