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Trends Cardiovasc Med. 2015 Aug;25(6):529-36. doi: 10.1016/j.tcm.2014.12.014. Epub 2014 Dec 31.

What do we know about the cardiac benefits of exercise?

Author information

1
Cardiovascular Division, Beth Israel Deaconess Medical Center, Center for Life Sciences, Harvard Medical School, Boston, MA.
2
Cardiovascular Division, Beth Israel Deaconess Medical Center, Center for Life Sciences, Harvard Medical School, Boston, MA. Electronic address: arosenzweig@partners.org.

Abstract

Exercise has long been considered an essential element for sustaining cardiovascular health. A vast literature of clinical studies suggests that exercise serves as an effective intervention for the primary and secondary prevention of cardiovascular disease, although the optimal nature, intensity, and duration of exercise for maximizing these cardiovascular benefits remain unclear. On a molecular level, exercise induces physiologic growth of the heart primarily by driving cardiomyocyte hypertrophy, notably through the interconnected IGF-1-PI3K-AKT1 and C/EBPβ-CITED4 pathways. Here, we explore the range of clinical evidence supporting the cardiovascular benefits of exercise and outline the molecular pathways that play major roles in regulating these protective effects.

PMID:
25661031
PMCID:
PMC4490154
DOI:
10.1016/j.tcm.2014.12.014
[Indexed for MEDLINE]
Free PMC Article

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