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Gerontology. 2015;61(5):427-34. doi: 10.1159/000371708. Epub 2015 Feb 4.

Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review.

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  • 1Department of Dermatology, University of Michigan Medical School, Ann Arbor, Mich., USA.

Abstract

Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function.

PMID:
25660807
PMCID:
PMC4524793
DOI:
10.1159/000371708
[PubMed - indexed for MEDLINE]
Free PMC Article
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