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Environ Pollut. 2015 Apr;199:166-73. doi: 10.1016/j.envpol.2015.01.024. Epub 2015 Feb 4.

Temporal changes (1997-2012) of perfluoroalkyl acids and selected precursors (including isomers) in Swedish human serum.

Author information

1
Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE 10691, Stockholm, Sweden. Electronic address: wouter.gebbink@aces.su.se.
2
Department of Risk and Benefit Assessment, National Food Agency, SE 75126, Uppsala, Sweden.
3
Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE 10691, Stockholm, Sweden.

Abstract

Concentrations (including isomer patterns) and temporal changes (1997-2012) of perfluoroalkyl acids (PFAAs) and selected perfluorooctane sulfonate (PFOS) and perfluoroalkyl carboxylic acid (PFCA) precursors were determined in serum samples from Swedish women. Perfluorooctane sulfonamide (FOSA) and perfluorooctane sulfonamidoacetic acid (FOSAA), as well as its N-methyl and N-ethyl derivatives (MeFOSAA and EtFOSAA) were consistently detected. Highest PFOS precursor concentrations were found for EtFOSAA (before year 2000) or MeFOSAA and FOSAA (after 2000). Disappearance half-lives for all PFOS precursors were shorter compared to PFOS. 4:2/6:2 and 6:2/6:2 polyfluoroalkyl phosphate diesters (diPAPs) were detected in <60% of the samples, whereas 6:2/8:2 and 8:2/8:2 diPAPs were detected in >60% of the samples, but showed no significant change in concentrations over time. Linear and sum-branched isomers were quantified separately for three PFAAs and three precursors. Significant changes between 1997 and 2012 in the % linear isomer were observed for PFOA and FOSA (increase) and PFOS (decrease).

KEYWORDS:

Human serum; Isomers; PAPs; Per- and polyfluoroalkyl substances; Precursors; Temporal trend

PMID:
25660070
DOI:
10.1016/j.envpol.2015.01.024
[Indexed for MEDLINE]
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