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Mech Ageing Dev. 2015 Nov;151:93-100. doi: 10.1016/j.mad.2015.01.004. Epub 2015 Feb 7.

Serum copper to zinc ratio: Relationship with aging and health status.

Author information

1
National Institute of Health and Science on Aging (INRCA), Scientific and Technological Research Area, Nutrition and Ageing Centre, via Birarelli 8, 60100 Ancona, Italy. Electronic address: m.malavolta@inrca.it.
2
National Institute of Health and Science on Aging (INRCA), Scientific and Technological Research Area, Nutrition and Ageing Centre, via Birarelli 8, 60100 Ancona, Italy.

Abstract

The serum concentrations of copper (Cu) and zinc (Zn) are strictly regulated by compensatory mechanisms that act to stabilize them within certain ranges of nutritional intake. However, there are mechanisms that are built to decrease serum concentration of Zn and to increase serum concentration of Cu in the presence of inflammatory conditions, so that a common feature of several age-related chronic diseases is an increase of the Cu to Zn ratio (CZr). Although the clinical potential of CZr has been extensively investigated, few authors addressed the mechanisms that mainly contribute to the increase of CZr in serum during aging, which signals drive this change and how cells respond to these changes. This review focuses on this topic and discusses how an increase of CZr during aging could reflect the homeostatic shade from a general systemic "growth and reproduction" status typical of juvenile age to a "repair and maintenance" status that evolved to preserve health status during old age.

KEYWORDS:

Aging; Copper; Homeostasis; Inflammation; Zinc

PMID:
25660061
DOI:
10.1016/j.mad.2015.01.004
[Indexed for MEDLINE]
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