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Clin Radiol. 2015 May;70(5):515-22. doi: 10.1016/j.crad.2015.01.002. Epub 2015 Feb 7.

Pulmonary light-chain deposition disease: CT and pathology findings in nine patients.

Author information

1
Department of Radiology, St George's Hospital, Blackshaw Road, London, SW17 0QT, UK.
2
Department of Histopathology, Royal Brompton and Harefield NHS Trust, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, UK.
3
Department of Histopathology, Royal Brompton and Harefield NHS Trust, Sydney Street, London, SW3 6NP, UK.
4
Department of Histopathology, Royal Marsden Hospital, Fulham Road, SW3 6JJ, UK.
5
Department of Radiology, Royal Brompton and Harefield NHS Trust, Sydney Street, London, SW3 6NP, UK. Electronic address: david.hansell@rbht.nhs.uk.

Abstract

AIM:

To review the clinical features of nine patients with pulmonary light-chain deposition disease (LCDD) and record their high-resolution CT (HRCT) and histopathological findings.

MATERIALS AND METHODS:

Patients with a diagnosis of LCDD on lung biopsy specimen were retrospectively identified. The HRCT characteristics of nodules, cysts, and ancillary findings; change at follow-up; and histopathological findings were documented.

RESULTS:

Features common to all nine cases were thin-walled cysts. In seven cases, vessels traversing the cysts were identified. The majority of patients (8/9) had at least one pulmonary nodule. There was no zonal predominance of either cysts or nodules. The disease appeared stable in the majority of cases with no serial change in HRCT appearances (5/6 cases with follow-up data, mean duration 29 months).

CONCLUSION:

To the authors' knowledge, this is the largest series of pulmonary LCDD patients in the literature, and the first systematic assessment of HRCT findings. Pulmonary cysts are a unifying feature, usually with pulmonary nodules, and serial change on HRCT is unusual.

PMID:
25659938
DOI:
10.1016/j.crad.2015.01.002
[Indexed for MEDLINE]

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