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Nat Rev Microbiol. 2015 Mar;13(3):160-72. doi: 10.1038/nrmicro3402. Epub 2015 Feb 9.

Post-translational protein modifications in malaria parasites.

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Department of Microbiology, Faculty of Biomedical and Psychological Sciences, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
1] Biology of Host-Parasite Interactions Unit, Institut Pasteur, 25 rue du Dr. Roux, Paris 75015, France. [2] CNRS URA2581, Institut Pasteur, 25 rue du Dr. Roux, Paris 75015, France.
Medical Research Council Toxicology Unit, University of Leicester, Lancaster Road, Leicester, LE1 9HN, UK.


Post-translational modifications play crucial parts in regulating protein function and thereby control several fundamental aspects of eukaryotic biology, including cell signalling, protein trafficking, epigenetic control of gene expression, cell-cell interactions, and cell proliferation and differentiation. In this Review, we discuss protein modifications that have been shown to have a key role in malaria parasite biology and pathogenesis. We focus on phosphorylation, acetylation, methylation and lipidation. We provide an overview of the biological significance of these modifications and discuss prospects and progress in antimalarial drug discovery based on the inhibition of the enzymes that mediate these modifications.

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