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Vaccine. 2015 Mar 17;33(12):1433-9. doi: 10.1016/j.vaccine.2015.01.071. Epub 2015 Feb 7.

Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine.

Author information

1
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA. Electronic address: dfrasca@med.miami.edu.
2
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.

Abstract

Cytomegalovirus (CMV)-seropositivity has been shown to have a negative effect on influenza vaccine-specific antibody responses. In this paper, we confirm and extend these results showing for the first time, a negative association between CMV-seropositivity and B cell predictive biomarkers of optimal vaccine responses. These biomarkers are switched memory B cells and AID in CpG-stimulated B cell cultures measured before vaccination which positively correlate with the serum response to the influenza vaccine. We also found that CMV-seropositivity is associated with increased levels of B cell-intrinsic inflammation and these both correlate with lower B cell function. Finally, CMV-seropositivity is associated with decreased percentages of individuals responding to the vaccine in both young and elderly individuals.

KEYWORDS:

Aging; B cell biomarkers; CMV; Influenza vaccine

PMID:
25659271
PMCID:
PMC4352374
DOI:
10.1016/j.vaccine.2015.01.071
[Indexed for MEDLINE]
Free PMC Article

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