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Med Sci (Paris). 2015 Jan;31(1):93-7. doi: 10.1051/medsci/20153101018. Epub 2015 Feb 6.

[Structural diversity oriented synthesis to explore the living world].

[Article in French]

Author information

Université Grenoble Alpes;   - CNRS, département de pharmacochimie moléculaire, UMR 5063, F-38041 Grenoble Cedex, France.


Structural diversity oriented synthesis aims to fulfill the unoccupied tridimensional "chemical space" gap left by traditional chemical libraries. Through the development of novel synthetic strategies relying on divergent reactions, chemist is now able to realize in only two or three steps such library that ensures the access of a large number of products having a good quality in term of structural diversity. A few examples are presented to illustrate how this can be done in the context of increasing molecular complexity and diversity devoted to the discovery and optimization of bioactive compounds.

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