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Cell Stem Cell. 2015 Feb 5;16(2):111-2. doi: 10.1016/j.stem.2015.01.009.

Do mutational dynamics in stem cells explain the origin of common cancers?

Author information

1
MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: gcrossan@mrc-lmb.cam.ac.uk.
2
MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
3
MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: kjp@mrc-lmb.cam.ac.uk.

Abstract

For more than 60 years, we have known that the incidence of certain common human cancers increases with age. Recently in Science, Tomasetti and Vogelstein (2015) refined this model by providing a potential explanation, arguing that early random mutational events within individual stem cells of regenerating organs may underlie this correlation.

PMID:
25658366
DOI:
10.1016/j.stem.2015.01.009
[Indexed for MEDLINE]
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