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Surg Neurol Int. 2015 Jan 14;6:6. doi: 10.4103/2152-7806.149389. eCollection 2015.

Neurosurgery concepts: Key perspectives on dendritic cell vaccines, metastatic tumor treatment, and radiosurgery.

Author information

1
Department of Neurosurgery, Stanford School of Medicine, Washington DC, USA.
2
Department of Neurosurgery, George Washington University, Washington DC, USA.
3
Department of Neurosurgery, Ajou University School of Medicine, Gyeonggi-do, South Korea.
4
Department of Neurosurgery, Johns Hopkins School of Medicine, Maryland, USA.
5
Department of Neurosurgery, University of California San Diego, CA, USA.
6
Department of Neurosurgery, Beaumont Hospital, Grosse Pointe, MI, USA.
7
Department of Neurosurgery, Seoul National University College of Medicine, Seoul, South Korea.
8
Department of Neurosurgery, University of California San Francisco, CA, USA.
9
Department of Neurosurgery, Keck School of Medicine at University of Southern California, CA, US.
10
Department of Neurosurgery, Northwestern Feinberg School of Medicine, IL, US.
11
Department of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, CA, US.

Abstract

BACKGROUND:

This is a laboratory study to investigate the effect of adding brain-derived-neurotrophic factor (BDNF) in a poly (N-isopropylacrylamide-g-poly (ethylene glycol) scaffold and its effect on spinal cord injury in a rat model.

METHODS:

This is a laboratory investigation of a spinal cord injury in a rat model. A dorsolateral funiculotomy was used to disrupt the dorsolateral funiculus and rubrospinal tract. Animals were then injected with either the scaffold polymer or scaffold polymer with BDNF. Postoperatively, motor functions were assessed with single pellet reach to grasp task, stair case reaching task and cylinder task. Histological study was also performed to look at extent of glial scar and axonal growth.

RESULTS:

Animals received BDNF containing polymer had an increased recovery rate of fine motor function of forelimb, as assessed by stair case reaching task and single pellet reach to grasp task compared with control animals that received the polymer only. There is no significant difference in the glial scar formation. BDNF treated animals also had increased axon growth including increase in the number and length of the rubrospinal tract axons.

CONCLUSION:

BDNF delivered via a scaffold polymer results in increased recovery rate in forelimb motor function in an experimental model of spinal cord injury, possibly through a promotion of growth of axons of the rubrospinal tract.

KEYWORDS:

Gamma Knife; Radiosurgery; dens fracture; glioblastoma; immunotherapy; meningiomas; metastasis

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