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J Neuroimaging. 2015 Sep-Oct;25(5):799-806. doi: 10.1111/jon.12193. Epub 2015 Feb 6.

Heterogeneity of Multiple Sclerosis White Matter Lesions Detected With T2*-Weighted Imaging at 7.0 Tesla.

Author information

1
Advanced Magnetic Resonance Imaging Section Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD.
2
Neuroimaging Center, Kessler Foundation, West Orange, NJ.
3
Neuroimmunology Branch, NINDS, NIH, Bethesda, MD.
4
Department of Bioengineering, Volgenau School of Engineering, George Mason University, Fairfax, VA.
5
Neurology Department, University of Maryland, Baltimore, MD.

Abstract

BACKGROUND AND PURPOSE:

Postmortem studies in multiple sclerosis (MS) indicate that in some white matter lesions (WM-Ls), iron is detectable with T2*-weighted (T2*-w), and its reciprocal R2* relaxation rate, magnetic resonance imaging (MRI) at 7.0 Tesla (7T). This iron appears as a hyperintense rim in R2* images surrounding a hypointense core. We describe how this observation relates to clinical/radiological characteristics of patients, in vivo.

METHODS:

We imaged 16 MS patients using 3T and 7T scanners. WM-Ls were identified on T1-w / T2-w 3T-MRIs. Thereafter, WM-Ls with a rim of elevated R2* at 7T were counted and compared to their appearance on conventional MRIs.

RESULTS:

We counted 36 WM-Ls presenting a rim of elevated R2* in 10 patients. Twenty-three (64%) lesions coincided with focal WM-Ls on T2-w MRIs; 13 (36%) coincided with only portions of larger lesions on T2-w images; and 20 (56%) corresponded to a hypointense chronic black hole. WM-Ls presenting a rim of elevated R2* were seen in both relapsing-remitting patients with low disability and in those with long-standing secondary progressive MS.

CONCLUSIONS:

WM-Ls with a contour of high R2* are present at different MS stages, potentially representing differences in the contribution of iron in MS disease evolution.

KEYWORDS:

7.0 tesla; Multiple sclerosis; T2*-weighted; iron; magnetic resonance imaging

PMID:
25657078
PMCID:
PMC5613291
DOI:
10.1111/jon.12193
[Indexed for MEDLINE]
Free PMC Article

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