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Clin Colorectal Cancer. 2015 Jun;14(2):63-71. doi: 10.1016/j.clcc.2014.12.004. Epub 2014 Dec 24.

Clinical implications of intestinal stem cell markers in colorectal cancer.

Author information

1
Molecular Unit, Department of Pathology, Herlev University Hospital, Herlev, Denmark; Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark. Electronic address: mlme@ruc.dk.
2
Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark; Department of Surgery, Roskilde Hospital, Roskilde, Denmark.
3
Molecular Unit, Department of Pathology, Herlev University Hospital, Herlev, Denmark.
4
Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark.

Abstract

Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell-specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance.

KEYWORDS:

BMI1; Biomarkers; LGR5; MSI1; SOX9

PMID:
25657049
DOI:
10.1016/j.clcc.2014.12.004
[Indexed for MEDLINE]
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