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Ann Neurol. 1989 Apr;25(4):398-403.

N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?

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1
Department of Neurology, Stanford University Medical Center, CA 94305.

Abstract

Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors may offer a new approach for the treatment of ischemic brain injury. This strategy is supported by a well-developed scientific foundation and encouraging results in a variety of in vivo and in vitro experimental models. Several specific antagonists, including MK-801, dextrorphan, dextromethorphan, and ketamine, have already been used at low doses in humans for other indications and are potential candidates for Phase I clinical trials.

PMID:
2565699
DOI:
10.1002/ana.410250412
[Indexed for MEDLINE]
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