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Blood. 2015 Mar 26;125(13):2075-8. doi: 10.1182/blood-2014-08-596734. Epub 2015 Feb 5.

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice.

Author information

1
Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA; Department of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA;
2
Biotech Research and Innovation Center, Center for Epigenetics, and The Danish Stem Cell Center, University of Copenhagen, Copenhagen, Denmark; and.
3
Stem Cell Group, University College London Cancer Institute, University College London, London, United Kingdom.

Abstract

Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer; however, its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias. Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrow increased peripheral blood T cells and, following secondary transplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential.

PMID:
25655602
PMCID:
PMC4467872
DOI:
10.1182/blood-2014-08-596734
[Indexed for MEDLINE]
Free PMC Article

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