Format

Send to

Choose Destination
J Clin Invest. 2015 Jan;125(1):65-74. doi: 10.1172/JCI73944. Epub 2015 Jan 2.

Autophagy and neurodegeneration.

Abstract

Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. Finally, we briefly describe some of the signaling pathways that may be amenable to therapeutic targeting for these goals.

PMID:
25654552
PMCID:
PMC4382230
DOI:
10.1172/JCI73944
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center