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J Clin Invest. 2015 Jan;125(1):25-32. doi: 10.1172/JCI73939. Epub 2015 Jan 2.

mTOR: a pharmacologic target for autophagy regulation.

Abstract

mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of cues, and its signaling pathway is deregulated in many human diseases. mTOR also plays a crucial role in regulating autophagy. This Review provides an overview of the mTOR signaling pathway, the mechanisms of mTOR in autophagy regulation, and the clinical implications of mTOR inhibitors in disease treatment.

PMID:
25654547
PMCID:
PMC4382265
DOI:
10.1172/JCI73939
[Indexed for MEDLINE]
Free PMC Article

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