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ScientificWorldJournal. 2015;2015:239815. doi: 10.1155/2015/239815. Epub 2015 Jan 12.

Isolated vitamin D deficiency is not associated with nonthyroidal illness syndrome, but with thyroid autoimmunity.

Author information

1
Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
2
Department of Biochemistry, Diskapi Training and Research Hospital, 06330 Ankara, Turkey.
3
Department of Endocrinology and Metabolism, School of Medicine, Ankara University, 06230 Ankara, Turkey.
4
Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey ; Translational Research Center, Diskapi Teaching and Research Hospital, 06330 Ankara, Turkey ; Department of Internal Medicine, School of Medicine (Kastamonu), Hacettepe University, 06330 Ankara, Turkey.

Abstract

AIM:

This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level.

MATERIALS AND METHODS:

The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated.

RESULTS:

Anti-TPO positivity was significantly more common in those with severe and moderate vitamin D deficiency, as compared to those with a normal 25(OH)D level. Furthermore, TSH levels were significantly lower in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level. Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant.

CONCLUSIONS:

The prevalence of thyroid autoantibody positivity was higher in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto's thyroiditis and NTIS.

PMID:
25654127
PMCID:
PMC4306373
DOI:
10.1155/2015/239815
[Indexed for MEDLINE]
Free PMC Article

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