Format

Send to

Choose Destination
J Physiol. 2015 Jun 15;593(12):2605-15. doi: 10.1113/jphysiol.2014.287607. Epub 2015 Mar 18.

The KCNQ1 channel - remarkable flexibility in gating allows for functional versatility.

Author information

1
Department of Physiology and Biophysics, University of Miami, Miami, FL 33136, USA.

Abstract

The KCNQ1 channel (also called Kv7.1 or KvLQT1) belongs to the superfamily of voltage-gated K(+) (Kv) channels. KCNQ1 shares several general features with other Kv channels but also displays a fascinating flexibility in terms of the mechanism of channel gating, which allows KCNQ1 to play different physiological roles in different tissues. This flexibility allows KCNQ1 channels to function as voltage-independent channels in epithelial tissues, whereas KCNQ1 function as voltage-activated channels with very slow kinetics in cardiac tissues. This flexibility is in part provided by the association of KCNQ1 with different accessory KCNE β-subunits and different modulators, but also seems like an integral part of KCNQ1 itself. The aim of this review is to describe the main mechanisms underlying KCNQ1 flexibility.

PMID:
25653179
PMCID:
PMC4500346
DOI:
10.1113/jphysiol.2014.287607
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center